Virginiamycin B is a depsipeptide antibiotic co-produced with ostreogrycin A and used as a synergistic mixture. Virginiamycin B, also known as ostreogrycin B and streptogramin B among other synonyms, was discovered independently and named by several groups leading to considerable confusion in the literature. Viriginiamycin B acts as a synergist binding to the conformational change in the peptidyl transferase centre of the 50S ribosome induced by ostreogrycin A.
Vigriniamycin B from Streptomyces sp.
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.