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uPAR (Urokinase Plasminogen Activator Surface Receptor, U-PAR, Monocyte Activation Antigen Mo3, CD87, PLAUR, MO3)

Cat no: U2610-04K

Supplier: United States Biological
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uPAR (Urokinase plasminogen activator receptor) is a 55kD glycoprotein I-anchored surface receptor specific for urokinase plasminogen activator (uPA). Upon binding to uPAR, uPA converts the surface bound, large serum b-globulin, plasminogen to plasmin. Plasmin, which is also designated fibrinolysin, is a trypsin-like enzyme that acts on Arg-Lys bonds and induces pericellular proteolysis in fibrin and fibrinogen, and thereby contributes to the systematic activation of the coagulation cascade. uPA and uPAR are known to be overexpressed in mesenchymal and epithelial tumor cells and are required for tumor invasion and metastasis. Applications: Suitable for use in Neutralizaztion, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Neutralization: 2-4ug/ml Western Blot: 0.5-2ug/ml Immunoprecipitation: 5-10ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: U2610-04K
Reactivities: Human
Hosts: Goat
Applications: Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
Additional info: Recognizes human uPAR at ~55kD

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