Home  >  Products  >  TBLR1 (F-box-like/WD Repeat-containing Protein TBL1XR1, Nuclear Receptor Corepressor/HDAC3 Complex Subunit TBLR1, TBL1-related Protein 1, Transducin beta-like 1X-related Protein 1, TBL1XR1, IRA1)
TBLR1 (F-box-like/WD Repeat-containing Protein TBL1XR1, Nuclear Receptor Corepressor/HDAC3 Complex Subunit TBLR1, TBL1-related Protein 1, Transducin beta-like 1X-related Protein 1, TBL1XR1, IRA1)

TBLR1 (F-box-like/WD Repeat-containing Protein TBL1XR1, Nuclear Receptor Corepressor/HDAC3 Complex Subunit TBLR1, TBL1-related Protein 1, Transducin beta-like 1X-related Protein 1, TBL1XR1, IRA1)

Cat no: T1845-10F

Supplier: United States Biological
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Chromatin organization plays a fundamental role in regulating transcription in eukaryotic cells. The nuclear receptor corepressor (N-CoR) and silencing mediator of retinoid and thyroid homone receptors (SMRT) play a role in diverse transcriptional repression pathways. N-CoR and SMRT each exist in large protein complexes, and are thought to mediate repression, at least in part, by their ability to recruit histone deacetylases to generate repressive chromatin. HDAC3 is the main HDAC that associates with N-CoR and SMRT complexes, and its presence is thought to be essential for repression. TBLR1 is a WD-40 repeat protein that also associates with N-CoR and SMRT complexes. Although TBLR1 is thought to be a core component of both the N-CoR and SMRT complexes, its role in these complexes remains to be elucidated. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-4ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T1845-10F
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by Protein A affinity chromatography.
Additional info: Recognizes human TBLR1. Species Crossreactivity: mouse and rat.

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