TAB1 (TAK1 binding protein 1) is an adaptor protein that can activate TAK1 in vivo through phosphorylation of TAK1, a mitogen-activated protein kinase kinase kinase. Once activated TAK1 phosphorylates MAPK kinase MKK4 and MKK3/6, which activate p38 MAPK and JNK, respectively.
Suitable for use in Western Blot. Other applications not tested.
Western Blot: 1-4ug/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.