Syntrophin (alpha-1) is a peripheral membrane protein located at the neuromuscular junction. Syntrophin (alpha-1) is expressed at high levels in skeletal muscle and heart, and at lower levels in brain, pancreas, liver, kidney and lung. It is an adaptor protein which is thought to bind and organise the subcellular localisation of membrane proteins such as utrophin and acetylcholine receptor. Syntrophin (alpha-1) also binds phosphatidylinositol 4,5-bisphosphate, it may link various receptors to the dystrophin glycoprotein complex and the actin cytoskeleton.
Suitable for use in ELISA and Western Blot. Other applications not tested.
Western Blot: 0.1-0.5ug/ml detects a band of ~60kD in human brain cell lysates. A minimum incubation time of 1 hour is recommended with this antibody.
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.