The synapsins are a family of at least five proteins that are specifically associated with the cytoplasmic surface of synaptic vesicles (1, 2). They are neuron-specific phosphoproteins that selectively bind to small synaptic vesicles in the presynaptic nerve terminal (3). The synapsins
are implicated in neurotransmitter release and synaptogenesis, a processes believed to be aberrant in several neuropsychiatric diseases (1).Synapsin II has been reported to specifically be involved in the formation and maintenance of synapses in hippocampal neurons (4). It has
also been found to play a distinct role in neuronal development, as a study reported that the deletion of synapsin II greatly retarded axon formation, and the deletion of synapsin I retarded synapse formation (5).Synapsin II was furthermore suggested to participate in cytoskeletal
organization during the early stages of nerve cell
development (6).
Applications:
Suitable for use in Flow Cytometry, Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended Dilution:
Flow Cytometry: 1:100
Western Blot: 1:5000-1:20,000
Immunohistochemistry: 1:100-1:250
Immunocytochemistry: 1:100-1:250
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
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