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Synapsin I, phosphorylated (Ser9) (Synapsin-1, Syn1)

Cat no: S9104-01M

Supplier: United States Biological
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Synapsin I plays a key role in synaptic plasticity in brain. This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. In addition to its role in plasticity, the expression of synapsin I is a precise indicator of synapse formation. Thus synapsin I immunocytochemistry provides a valuable tool for the study of synaptogenesis. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation. Serine 9 is the site on synapsin I that is phosphorylated by cAMP-dependent protein kinase and by calcium calmodulin kinase I. Phosphorylation of this site is thought to regulate synaptic vesicle function. Applications: Suitable for use in Western Blot.. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Positive Control: Rat brain Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S9104-01M
Reactivities: Human, Mouse, Rat, Xenopus/Amphibian
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in 10mM HEPES (pH 7.5), 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Frederikse PH, Yun E, Kao HT, Zigler JS Jr, Sun Q, Qazi AS. 2004. Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation. Molecular Vision 10:794-804. 2. Kao, H.T., Song, H.J., Porton, B., Ming, G.L., Hoh, J., Abraham, M., Czernik, A.J., Pieribone, V.A., Poo, M.M. and Greengard, P.
Additional info: Recognizes rat Synapsin I, phosphorylated at (Ser9). Species crossreactivity: mouse, human and xenopus.

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