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Synapsin I, phosphorylated (Ser62/Ser67) (Synapsin 1, Syn1)

Synapsin I, phosphorylated (Ser62/Ser67) (Synapsin 1, Syn1)

Cat no: S9104-04E

Supplier: United States Biological
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Synapsins are involved in neurotransmitter release. Synapsin I cross-links synaptic vesicles and cytoskeleton. The interactions of the protein with actin filaments and synaptic vesicle are regulated by phosphorylation. Synapsin I has many potential phosphorylation sites available to different enzymes, serines 62 and 67 are phosphorylated by extracellular signal-regulated kinases 1 and 2 of the mitogen-activated protein (MAP) kinase superfamily. Map-kinase phosphorylation of synapsins is a key step in the modulation of neurotransmitter release by brain-derived neurotrophic factor. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S9104-04E
Reactivities: Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in 10mM Hepes, pH 7.5, 150mM sodium chloride, 0.09% sodium azide, 0.01% BSA, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Matsubara M, et al (1996) Site-specific phosphorylation of synapsin I by mitogen-activated protein kinase and Cdk5 and its effects on physiological functions. J. Biol. Chem. 271:21108-27113
Additional info: Recognizes rat synapsin I when phosphorylated at Ser62 and Ser67. Species sequence homology: Bovine, Mouse.

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