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Synapsin I, phosphorylated (Ser549) (Synapsin 1, Syn1)

Cat no: S9104-04D

Supplier: United States Biological
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Synapsin I is a 78kD member of the synapsin family, expressed in the central and peripheral nervous system. Synapsins coat synaptic vesicles, binding them to the cytoskeleton and are thought to regulate their availability for release. Synapsins are important in brain plasticity, axonogenesis and synaptogenesis. Mutations in the synapsin I gene may be associated with disorders such as X-linked recessive epilepsy associated with variable learning disabilities and behavior disorders. Phosphorylation of serine residue 549 by MAP kinase or cyclin-dependent kinases 1 or 5 is an important part in modulating synaptic vesicle trafficking. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S9104-04D
Reactivities: Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in 10mM Hepes, pH 7.5, 0.09% sodium azide, 0.01% BSA, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Baldelli, P. et al. (2005) Synapsins and neuroexocytosis: recent views from functional studies on synapsin null mutant mice. Arch. Ital. Biol. 143:113-26. 2. Garcia, C. et al. (2004) Identification of a mutation in synapsin I, a synaptic vesicle protein, in a family with epilepsy. J. Med. Genet. 41:183-187.
Additional info: Recognizes rat synapsin I, phosphorylated at serine residue 549. Species sequence homology: Human, Bovine, Dog, Mouse, Primate.

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