Synapsin I is a 78kD member of the synapsin family, expressed in the central and peripheral nervous system. Synapsins coat synaptic vesicles, binding them to the cytoskeleton and are thought to regulate their availability for release. Synapsins are important in brain plasticity, axonogenesis and synaptogenesis. Mutations in the synapsin I gene may be associated with disorders such as X-linked recessive epilepsy associated with variable learning disabilities and behavior disorders.
Phosphorylation of serine residue 549 by MAP kinase or cyclin-dependent kinases 1 or 5 is an important part in modulating synaptic vesicle trafficking.
Suitable for use in Western Blot. Other applications not tested.
Western Blot: 1:1,000
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.