Home  >  Products  >  Survivin, CT (Apoptosis Inhibitor 4, Apoptosis Inhibitor-4, API4, Apoptosis Inhibitor Survivin, Baculoviral IAP Repeat-containing Protein 5, BIRC5, BIRC-5, EPR1, EPR-1, IAP4, SVV, TIAP)
Survivin, CT (Apoptosis Inhibitor 4, Apoptosis Inhibitor-4, API4, Apoptosis Inhibitor Survivin, Baculoviral IAP Repeat-containing Protein 5, BIRC5, BIRC-5, EPR1, EPR-1, IAP4, SVV, TIAP)

Survivin, CT (Apoptosis Inhibitor 4, Apoptosis Inhibitor-4, API4, Apoptosis Inhibitor Survivin, Baculoviral IAP Repeat-containing Protein 5, BIRC5, BIRC-5, EPR1, EPR-1, IAP4, SVV, TIAP)

Cat no: S8500-02Q

Supplier: United States Biological
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Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins.?IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP. Survivin:TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin:TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas. Applications: Suitable for use in Immunofluorescence, Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Immunofluorescence: 10ug/ml Western Blot: 0.5-1ug/ml Immunocytochemistry: 10ug/ml Optimal dilutions to be determined by the researcher. Positive Control: MOLT4 cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S8500-02Q
Reactivities: Human
Hosts: Rabbit
Applications: Immunocytochemistry, Immunofluorescence, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Ambrosini G, Adida C, Altieri DC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 1997;3:917-21. 2. Li F, Ambrosini G, 3. Kobayashi K, Hatano M, Otaki M, Ogasawara T, Tokuhisa T. Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation. Proc Natl Acad Sci
Additional info: Recognizes human Survivin (CT).

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