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Superoxide Dismutase 2 (SOD2)

Cat no: S8060-10R2


Supplier: United States Biological
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Superoxide dismutase (SOD)is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2-) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. These include intracellular copper, zinc SOD (Cu,Zn-SOD/SOD-1), mitochondrial manganese SOD (Mn-SOD/SOD-2) and extracellular Cu,Zn-SOD (EC-SOD/SOD-3). SOD1 isfound in all eukaryotic species as a homodimeric 32kD enzyme containing one each of Cu and Zn ion per subunit. The manganese containing 80kD tetrameric enzyme SOD2, is located in the mitochondrial matrix in close proximity to primary endogenous source of superoxide,the mitochondrial respiratory chain. SOD3 is aheparin-binding multimer of disulfide-linked dimers, primarily expressed in human lungs, vessel walls and airways.SOD4 is a copper chaperone for superoxidedismutase (CCS), which specifically delivers Cu to copper/zinc superoxide dismutase.CCS may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor. Applications: Suitable for use in Immunoprecipitation. Other applications not tested. Recommended Dilution: Immunoprecipitation: 1-2ul/400ul lysates. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S8060-10R2
Reactivities: Human
Hosts: Mouse
Applications: Immunoprecipitation
Size: 100ug
Form: Supplied as a liquid.
P type: Mab
Isotype: IgG1,k
Purity: Ascites
Additional info: Recognizes human Superoxide Dismutase 2.

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