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Substance P (NKA, NKNA, TAC2)

Substance P (NKA, NKNA, TAC2)

Cat no: S8000-12A

Supplier: United States Biological
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The COOH terminal end of substance P, a short polypeptide neurotransmitter that regulates the excitability of dorsal horn nociceptive neurons. It is known to have a role in several physiologic activities such as pain transmission, the vomiting reflex, salivary secretion and smooth muscle contraction. Applications: Suitable for use in Immunofluorescence and Immunohistochemistry (frozen and paraffin). Other applications not tested. Recommended Dilution: Immunohistochemistry (frozen): 1:100-1:200 Immunohistochemistry (paraffin): 1:100-1:200 Optimal dilutions to be determined by the researcher. Hybridoma: NS1/1-Ag 4-1 myeloma cells with spleen cells from Wistar rat. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S8000-12A
Hosts: Rat
Applications: Immunofluorescence, Immunohistochemistry
Size: 100ul
Form: Supplied as a liquid, 0.09% thiomersal.
P type: Mab
Isotype: IgG2a
Purity: Supernatant
References: 1. Cuello, A.C. et al. (1980) Use of monoclonal antibodies in immunohistochemistry with special reference to the central nervous system. Brain Res. Bull. 5: 575-587. 2. Pioro, E.P. et al. (1985) Loss of substance P immunoreactivity in the nucleus of the spinal trigeminal tract after intradural tumour compression of the trigeminal nerve. Neurosci Lett. 58: 7-12. 3. Mai, J.K. et al. (1986) Substance P in the human brain. Neuroscience 17: 709-739. 4. Cuello, A.C. et al. (1979) Detection of substance P in the central nervous system by a monolconal antibody. Proc. Natl. Acad. Sci. USA 76: 3532-3536.
Additional info: Recognizes the COOH terminal end of substance P. 5% reactivity is observed with eledoisin. It does not react with Leu or Met-enkephalin, somatostatin or beta-endorphin.

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