Home  >  Products  >  Structural Maintenance of Chromosomes 1, phosphorylated (Ser957) (SMC1, Structural Maintenance of Chromosomes Protein 1A, SMC Protein 1A, SMC-1-alpha, SMC1alpha, SMC1A, SMC-1A, CDLS2, DKFZp686L19178, DXS423E, KIAA0178, MGC138332, Sb1.8, SMC1L1, SMCB)
Structural Maintenance of Chromosomes 1, phosphorylated (Ser957) (SMC1, Structural Maintenance of Chromosomes Protein 1A, SMC Protein 1A, SMC-1-alpha, SMC1alpha, SMC1A, SMC-1A, CDLS2, DKFZp686L19178, DXS423E, KIAA0178, MGC138332, Sb1.8, SMC1L1, SMCB)

Structural Maintenance of Chromosomes 1, phosphorylated (Ser957) (SMC1, Structural Maintenance of Chromosomes Protein 1A, SMC Protein 1A, SMC-1-alpha, SMC1alpha, SMC1A, SMC-1A, CDLS2, DKFZp686L19178, DXS423E, KIAA0178, MGC138332, Sb1.8, SMC1L1, SMCB)

Cat no: S7980-01U

Supplier: United States Biological
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SMC1 is a member of the structural maintenance of chromosomes family. It was originally identified in Saccharomyces sereviciae as a component of cohesin, a protein complex that is required for maintenance of sister chromatid cohesion. SMC1 was also reported to be present in a biochemically defined mammalian protein complex, called RC-1, which promotes DNA recombination. The protein was recently shown to be a target of the ATM kinase with phosphorylation of Ser 957 and Ser 966 of SMC1 occurring in an ATM-dependent manner after ionizing irradiation. The protein thus participates in cellular responses to DNA damage. Human SMC1 gene is localized on chromosomal region Xp11.22-p11.21. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Immunohistochemistry (paraffin): 1:50-1:100 Optimal dilutions to be determined by the researcher. Positive Control: K562 cells Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S7980-01U
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Risa, K. et al. Genes and Development. 18:1423-1438 (2004). 2. Seong-Tae, K. et al. Genes and Development. 16:560-570 (2002).
Additional info: Recognizes human SMC1 when phosphorylated at Ser957. Species Crossreactivity: mouse.

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