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Stromal Interaction Molecule 1 (STIM1, GOK)

Cat no: S7975-88G


Supplier: United States Biological
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STIM1 is a ubiquitously expressed 84kD highly hydrophobic type I transmembrane protein, which acts as an essential component of store-operated Ca2+ (SOC) channel function, and hence normal cell function. STIM1 acts as a calcium sensor which, in response to depletion in the intracellular calcium store, translocates from the endoplasmic reticulum (ER) to the plasma membrane and activates calcium release-activated calcium (CRAC) channels. Applications: Suitable for use in Immunoprecipitation and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S7975-88G
Reactivities: Mouse, Rat
Hosts: Mouse
Applications: Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein A affinity chromatography.
References: 1. Zhang, S.L. et al. (2005) STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane. Nature. 437: 902-905.
Additional info: Recognizes STIM1. Species Crossreactivity: rat, mouse.

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