STIM1 is a ubiquitously expressed 84kD highly hydrophobic type I transmembrane protein, which acts as an essential component of store-operated Ca2+ (SOC) channel function, and hence normal cell function. STIM1 acts as a calcium sensor which, in response to depletion in the intracellular calcium store, translocates from the endoplasmic reticulum (ER) to the plasma membrane and activates calcium release-activated calcium (CRAC) channels.
Suitable for use in Immunoprecipitation and Western Blot. Other applications not tested.
Western Blot: 1-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.