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STIM1 (Stromal Interaction Molecule 1, GOK)

STIM1 (Stromal Interaction Molecule 1, GOK)

Cat no: S7975-88L

Supplier: United States Biological
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In T lymphocytes, the sole pathway for Ca++ entry following antigen-receptor binding is through store-operated Ca++- release-activated Ca++ (CRAC) channels. These channels are made up of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), a protein that functions as a Ca++ sensor and activates the CRAC channels, migrating to the plasma membrane from endoplasmic reticulum (ER)-like sites, which act as the Ca++ store. A related molecule, STIM2, acts to inhibit the STIM1-mediated store-operated Ca++ entry, and can form complexes with STIM1, suggesting they may play a coordinated role in controlling Ca++ entry. At least two isoforms of STIM1 are known to exist; this antibody will detect only the larger form. This STIM1 antibody is predicted to have no cross-reactivity to STIM2. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Mouse thymus tissue lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S7975-88L
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified
References: 1. Luik RM, et al (2007) Trends Mol. Med. 13:103-7. 2. Feske S, et al (2006) Nature. 441:179-85. 3. Zhang SL, et al (2005) Nature. 437:902-5. 4. Spassova MA, et al (2006) Proc. Natl. Acad. Sci. USA. 103:4040-5. 5. Soboloff J, et al (2006) Curr. Biol. 16:1465-70.
Additional info: Recognizes human STIM1. Species Crossreactivity: mouse and rat.

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