Home  >  Products  >  STE20-related Kinase Adapter Protein alpha (STE20-related Kinase Adaptor alpha, STRAD alpha, STRADA, STRAD, FLJ90524, LYK5, NY-BR-96, PMSE, Serologically Defined Breast Cancer Antigen, STE20-related Adapter Protein, Stlk)
STE20-related Kinase Adapter Protein alpha (STE20-related Kinase Adaptor alpha, STRAD alpha, STRADA, STRAD, FLJ90524, LYK5, NY-BR-96, PMSE, Serologically Defined Breast Cancer Antigen, STE20-related Adapter Protein, Stlk)

STE20-related Kinase Adapter Protein alpha (STE20-related Kinase Adaptor alpha, STRAD alpha, STRADA, STRAD, FLJ90524, LYK5, NY-BR-96, PMSE, Serologically Defined Breast Cancer Antigen, STE20-related Adapter Protein, Stlk)

Cat no: S7972-73D

Supplier: United States Biological
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Members of STE-20 like kinase family are known to stimulate MAPK pathways by directly activating MAPKKK. STRAD is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. STRAD-LKB1 interaction results in phosphorylation of STRAD and enhanced autophosphorylation of LKB1. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: A549 Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S7972-73D
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity Chromatography.
References: 1. Baas et.al EMBO J. 22(12): 3062
Additional info: Recognizes human STE20-related adaptor protein/STRAD. Species sequence homology: mouse, rat, canine, bovine.

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