Home  >  Products  >  Stathmin 1, CT (Stathmin-1, STMN1, Stathmin, SMN, Lag, Leukemia-associated Phosphoprotein p18, LAP18, Metablastin, Oncoprotein 18, OP18, p18, p19, Phosphoprotein 19, Phosphoprotein p19, PP17, PP19, PR22, Pr22 Protein, Prosolin, Protein Pr22)

Stathmin 1, CT (Stathmin-1, STMN1, Stathmin, SMN, Lag, Leukemia-associated Phosphoprotein p18, LAP18, Metablastin, Oncoprotein 18, OP18, p18, p19, Phosphoprotein 19, Phosphoprotein p19, PP17, PP19, PR22, Pr22 Protein, Prosolin, Protein Pr22)

Cat no: S7972-50G


Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Stathmin (oncoprotein 18, op18) is a ubiquitous cytosolic phosphoprotein with various regulatory functions in cell proliferation, differentiation signaling, and activation (1). In particular, stathmin is involved in the regulation of tubulin dynamics through inhibition of microtubule formation and/or microtubule depolymerization. Stathmin interacts with soulable tubulins (a,b-tubulin) resulting in the formation of T2S complex which sequesters free tubulin, impeding tubulin formation (2). Stathmin activity is regulated through phosphorylation at Ser16, Ser25, Ser38 and Ser63 by various protein kinases (e.g. MAP-kinase, p34cdc2 kinase), weakening stathmins affinity to tubulin (3). A mutation on stathmin can lead to excess build up of mitotic spindle and with possible consequence of unregulated cell cycles seen in cancer cells (4). Stathmin is also known as the generic member of a protein family which includes neural proteins SCG10, SCLIP and RB3/RB3'/RB3". All members in this family exhibits tubulin binding ability. Applications: Suitable for use in Flow Cytometry, ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:15 Western Blot: 1:50,000 Immunoprecipitation: 1:50 Immunohistochemistry: 1:250-1:500 Immunocytochemistry: 1:100-1:250 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: S7972-50G
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50 mM Tris-Glycine (pH 7.4), 0.15 M sodium chloride, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Purified by Immunoaffinity Chromatography.
Alternative names: Phosphoprotein p19, pp19, Oncoprotein 18, Op18, Leukemia-associated phosphoprotein p18, pp17, Prosolin, Metablastin, Protein Pr22
References: 1.Cassimeris L et al. Curr Opin in Cell Bio. 14:18-24, 2002.3.Jourdain L et al. Biochemistry 36:10817-10821, 1997.4.Moreno FJ, Avila J, Mol Cell Biochem 183: 201-209, 1998
Additional info: Recognizes human Stathmin. Species Crossreactivity: Mouse and rat.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*

Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave