Home  >  Products  >  Stat 5 (Signal Transducer and Activator of Transcription 5, STAT5, Mammary Gland Factor, MGF, Signal Transducer and Activator of Transcription 5A, STAT5A, STAT5B, Transcription Factor STAT5A)
Stat 5 (Signal Transducer and Activator of Transcription 5, STAT5, Mammary Gland Factor, MGF, Signal Transducer and Activator of Transcription 5A, STAT5A, STAT5B, Transcription Factor STAT5A)

Stat 5 (Signal Transducer and Activator of Transcription 5, STAT5, Mammary Gland Factor, MGF, Signal Transducer and Activator of Transcription 5A, STAT5A, STAT5B, Transcription Factor STAT5A)

Cat no: S7972-07L2

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
A variety of cytokines and growth factors act through an induction of gene expression mediated by a family of latent transcription factors called STAT (Signal Transducers and Activators of Transcription) proteins. Cytokines, hormones and growth factors proceed through a sequence of steps that includes binding to receptors in the cytokine receptor superfamily followed by the activation of the JAK family of tyrosine kinases, which results in the activation of STAT proteins. The activated STATs then become dimerized and translocated into the nucleus where they initiate specific gene transcription. STAT 5 regulates growth, differentiation, and survival of mammary, hematopoietic cells, hematopoietic malignancies, or carcinogenesis. Constitutive activation of STAT 5 may contribute to tumorigenesis, thus dephosphorylation of STAT 5 may serve as a therapeutic strategy. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S7972-07L2
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Stancato, L. et al. J Biol Chem 271, 4134 (1996) 2. Su, L. et al. J Biol Chem 274, 31770 (1999) 3. Dimberg, A. et al. Blood 102, 254 (2003) 4. Maurer, A. et al. Blood 99, 2647 (2002).
Additional info: Recognizes human STAT5.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave