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STAT 4 (Signal Transducer and Activator of Transcription 4)

Cat no: S7972-02L


Supplier: United States Biological
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STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. STAT4 is activated when cells are treated with interleukin-12, a key cytokine regulator of cell-mediated immunity. Human STAT4 gene is mapped to chromosome 2q32.2-q32.3. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Immunohistochemistry (paraffin): 1:50-1:100 Optimal dilutions to be determined by the researcher. Positive Control: HeLa cells Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S7972-02L
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Holly A. et al. J. Biol. Chem. 273:17109-17114 (1998). 2. David, F. et al. J. Biol. Chem. 275:2693-2697 (2000).
Additional info: Recognizes human STAT4. Species Crossreactivity: mouse and rat.

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