When walking or running, the internal structure of the body experiences various mechanical stresses such as muscle movement, heart pulsation or skin tension while smiling. These mechanical stresses are closely related to cell proliferation and differentiation or tissue degeneration and development. Additionally, disease processes such as osteoporosis, cancer metastasis, skin disorders and muscle degeneration share a loss of tissue structure, integrity and mechanical transduction.The Mechanical Cell Stretch System, ShellPa, is an instrument for cell culturing that has been developed in order to replicate a dynamic environment inside the human body.This system is pneumatically driven by an air compressor. It is expected that cell culturing under the mechanical stress provided by this system can bring more biologically and physiologically realistic cell responses compared to a conventional static cell culturing without mechanical stress.System Features:The stretch frequency and stretch ratio (stretch pattern) are easily controllable.Stretch Chambers are made with silicone (polydimethylsiloxane, or PDMS) and can be used with this system after being coated (e.g. fibronectin).Lightweight & compactFits in standard laboratory incubatorStretch frequency: 1-120 cycle(s)/minStretch ratio: 2, 4, 5, 6, 8, 10, 12, 15 and 20%Use up to 6 stretch chamber simultaneouslyRemovable stretch chambers holderController clearly indicates the accumulated operation time
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