ST2V is a 259aa membrane protein belonging to the interleukin 1 receptor family with two transmembrane helices, one TIR domain and three Ig-like C2-type (immunoglobulin-like) domains. ST2V is a novel variant of human ST2 which has isoforms ST2L, ST2S, ST2V and ST2LV. It is usually expressed in the human leukemic cell line UT-7 and it's sublines UT-7:GM, UT-7:EPO, and UT-7:TPO, in addition to human helper T cell line 5C10. Reports suggest that it is possibly involved in helper T-cell function. ST2V can be induced by proinflammatory stimuli and is a receptor for interleukin-33 (IL-33). IL-33 binds to and signals through ST2V and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3:ERK1 and/or MAPK1:ERK2, MAPK14, and MAPK8. The possible roles of ST2V in growth and differentiation are intriguing. It is predominantly expressed in stomach, small intestine and colon.
Suitable for use in Western Blot. Other applications not tested.
Western Blot: 3-5ug/ml
Optimal dilutions to be determined by the researcher.
Daudi and NIH 3T3 cell lysate
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.