Home  >  Products  >  ST2 (Suppressor of Tumorigenicity 2, ST2L, ST2V, DER4, FIT-1, Homolog of Mouse Growth Stimulation-expressed, IL33R, Interleukin 1 Receptor-like 1, IL1RL1, Interleukin 1 Receptor-related Protein, Lymphocyte Antigen 84, Ly84, MGC32623, T1 Protein)
ST2 (Suppressor of Tumorigenicity 2, ST2L, ST2V, DER4, FIT-1, Homolog of Mouse Growth Stimulation-expressed, IL33R, Interleukin 1 Receptor-like 1, IL1RL1, Interleukin 1 Receptor-related Protein, Lymphocyte Antigen 84, Ly84, MGC32623, T1 Protein)

ST2 (Suppressor of Tumorigenicity 2, ST2L, ST2V, DER4, FIT-1, Homolog of Mouse Growth Stimulation-expressed, IL33R, Interleukin 1 Receptor-like 1, IL1RL1, Interleukin 1 Receptor-related Protein, Lymphocyte Antigen 84, Ly84, MGC32623, T1 Protein)

Cat no: S6606-50D

Supplier: United States Biological
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ST2 is a membrane protein belonging to the interleukin-1 receptor family with three Ig-like C2-type (immunoglobulin-like) domains and a TIR domain. ST2, also known as IL1RL1, is a receptor for interleukin-33 (IL-33) which upon stimulation recruits the signaling molecules MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3:ERK1 and/or MAPK1:ERK2, MAPK14, and MAPK8. Reports also suggest its possible role in helper T-cell function as well as in cell growth. Three isoforms of ST2 have been reported where isoform C is a membrane form and isoform B is a secreted form. ST2 may be induced by proinflammatory stimuli, and may also be found in serum of autoimmune disease. Different isoforms are restricted to different tissues while high expression of this protein is evident in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 4-5ug/ml Immunohistochemistry (formalin fixed paraffin embedded): 5ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Kidney Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S6606-50D
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Schmitz, J. et al. Biochem. Biophys. Res. Commun. 235:474-478 (1997). 2. Brint, EK. et al. Nature Immun. 5:373-379 (2004). 3. Kumar, S. et al. Immunity. 23:479-490 (2005).
Additional info: Recognizes human ST2/IL1RL1. Species Crossreactivity: chimpanzee. Species sequence homology: bovine, equine, mouse, orangutan, rhesus monkey.

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