Home  >  Products  >  ST2, NT (Suppressor of Tumorigenicity 2, ST2L, ST2V, DER4, Homolog of Mouse Growth Stimulation-expressed, Interleukin 1 Receptor-like 1, IL1RL1, Interleukin 1 Receptor-related Protein, Lymphocyte Antigen 84, Ly84, T1 Protein)
ST2, NT (Suppressor of Tumorigenicity 2, ST2L, ST2V, DER4, Homolog of Mouse Growth Stimulation-expressed, Interleukin 1 Receptor-like 1, IL1RL1, Interleukin 1 Receptor-related Protein, Lymphocyte Antigen 84, Ly84, T1 Protein)

ST2, NT (Suppressor of Tumorigenicity 2, ST2L, ST2V, DER4, Homolog of Mouse Growth Stimulation-expressed, Interleukin 1 Receptor-like 1, IL1RL1, Interleukin 1 Receptor-related Protein, Lymphocyte Antigen 84, Ly84, T1 Protein)

Cat no: S6606-50B

Supplier: United States Biological
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ST2 is a member of the Toll-interleukin 1 receptor (TIR) superfamily, expressed by mast cells and TH2 helper cells, but not by TH1 effector cells. The majority of TIR superfamily members, which includes the Interleukin-1 receptor (IL-1R1), Toll-like receptors (TLRs) and the cytosolic adaptor proteins MyD88, TIRAP, Trif and TRAM, initiate innate immunity through the ultimate activation of the transcription factor NF-kappaB and are inducers of the inflammatory response. In contrast ST2, which itself is unable to activate NF-kappaB, has been identified as a negative regulator of IL-1R1 and TLR4 signaling by sequestering MyD88 and TIRAP (1), in line with its role as a crucial receptor in TH2-cell mediated responses (2). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S6606-50B
Reactivities: Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Brint, E.K. et al. (2004) ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nature Immunol. 5: 373-379. 2. Coyle, A.J. et al. (1999) Crucial role of the Interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses. J. Exp. Med. 190: 895-902.
Additional info: Recognizes an epitope within the N-terminal region (NT) of mouse ST2.

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