Home  >  Products  >  ST2, NT (Suppressor of Tumorigenicity 2, ST2L, ST2V, DER4, FIT-1, Homolog of Mouse Growth Stimulation-expressed, IL33R, Interleukin 1 Receptor-like 1, IL1RL1, Interleukin 1 Receptor-related Protein, Lymphocyte Antigen 84, Ly84, MGC32623, T1 Protein)
ST2, NT (Suppressor of Tumorigenicity 2, ST2L, ST2V, DER4, FIT-1, Homolog of Mouse Growth Stimulation-expressed, IL33R, Interleukin 1 Receptor-like 1, IL1RL1, Interleukin 1 Receptor-related Protein, Lymphocyte Antigen 84, Ly84, MGC32623, T1 Protein)

ST2, NT (Suppressor of Tumorigenicity 2, ST2L, ST2V, DER4, FIT-1, Homolog of Mouse Growth Stimulation-expressed, IL33R, Interleukin 1 Receptor-like 1, IL1RL1, Interleukin 1 Receptor-related Protein, Lymphocyte Antigen 84, Ly84, MGC32623, T1 Protein)

Cat no: S6606-50E

Supplier: United States Biological
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ST2 is a member of a superfamily containing the interleukin-1 receptor and the Toll-like receptors (TLRs). The TLRs are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. ST2 was originally identified as a protein whose production was stimulated by various proliferation-inducing agents such as PDGF and FGF. More recently, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor (TLR) 4 signaling and to maintain endotoxin tolerance. It has been suggested that the inhibition of TLR4 signaling occurs through the association and sequestering of TLR adaptor molecules such as MyD88 and TIRAP. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Mouse kidney cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S6606-50E
Reactivities: Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003;21:335-76. 2. Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002;20:197-216. 3. Lanahan A, Williams JB, Sanders LK, et al. Growth factor-induced delayed early response genes. Mol Cell Biol. 1992;12:3919-29. 4. Sweet MJ, Leung BP, Kang D, et al. A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression. J. Immunol. 2001;166:6633-9. 5. Brint EK, Xu D, Liu H, et al. ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat. Immunol. 2004;5:373-9. 6. Liew FY, Liu H, and Xu D. A novel regulator for IL-1 and Toll-like receptor 4. Immunol. Lett. 2005;96:27-31.
Additional info: Recognizes mouse ST2 (NT).

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