Home  >  Products  >  Splicing Factor, Arginine/Serine-rich 2 (SFRS2, PR264, Protein PR264, SFRS2A, Splicing Component 35kD, SC 35, SC35, SC-35, Splicing Factor SC35, Splicing Speckle, Splicing Speckles, SRp30b)
Splicing Factor, Arginine/Serine-rich 2 (SFRS2, PR264, Protein PR264, SFRS2A, Splicing Component 35kD, SC 35, SC35, SC-35, Splicing Factor SC35, Splicing Speckle, Splicing Speckles, SRp30b)

Splicing Factor, Arginine/Serine-rich 2 (SFRS2, PR264, Protein PR264, SFRS2A, Splicing Component 35kD, SC 35, SC35, SC-35, Splicing Factor SC35, Splicing Speckle, Splicing Speckles, SRp30b)

Cat no: S5554-52A

Supplier: United States Biological
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SC35 is involved in pre-mRNA splicing and is found in the bodies in the nucleus referred to as speckles, SC 35 domains or splicing factor compartments (SFCs). The SC-35 clone is frequently used as a marker for these bodies, the role of which is controversial. Speckles correspond largely if not entirely to ultrastructures termed interchromatin granule clusters (IGCs). SC35 is excluded from the nucleolus. Applications: Suitable for use in Immunofluorescence, ELISA, Western Blot, Immunoprecipitation, and Immunohistochemistry (paraffin-embedded sections). Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Cellular Localization: Nuclear Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: S5554-52A
Reactivities: Human, Rat, Drosophila/Arthropod, Xenopus/Amphibian
Hosts: Mouse
Applications: ELISA, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid, 0.09% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Ascites
References: 1. Fu XD et al. General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection. Proc Natl Acad Sci U S A 89:11224-8 (1992).
Additional info: Recognizes a phospho-epitope on the non-snRNP (small nuclear ribonucleoprotein particles) factor SC-35. Reacts with the splicing factor SC-35 and with the SC-35-related non-snRNP factor SF2/ASF. Species Crossreactivity: Crossreacts with Human, Rat, Xenopus laevis, Drosophilia melanogaster and Newt.

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