Home  >  Products  >  SPG20 (Spastic Paraplegia 20 Protein, Trans-activated By Hepatitis C Virus Core Protein 1, Spartin, TAHCCP1, KIAA0610, Troyer syndrome)
SPG20 (Spastic Paraplegia 20 Protein, Trans-activated By Hepatitis C Virus Core Protein 1, Spartin, TAHCCP1, KIAA0610, Troyer syndrome)

SPG20 (Spastic Paraplegia 20 Protein, Trans-activated By Hepatitis C Virus Core Protein 1, Spartin, TAHCCP1, KIAA0610, Troyer syndrome)

Cat no: S4283-20A

Supplier: United States Biological
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This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome). Applications: Suitable for use in ELISA. Other applications have not been tested. Recommended Dilutions: Peptide ELISA Titer: 1:8000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S4283-20A
Reactivities: Human
Hosts: Goat
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by peptide affinity chromatography.
Alternative names: trans-activated by hepatitis C virus core protein 1, spastic paraplegia 20, spartin (Troyer syndrome), spastic paraplegia 20, OTTHUMP00000018254, TAHCCP1, SPARTIN, KIAA0610, spastic paraplegia 20 (Troyer syndrome), SPG20
References: 1. Lu J, Rashid F, Byrne PC. The hereditary spastic paraplegia protein spartin localises to mitochondria J Neurochem. 2006 Sep;98(6):1908-19. PMID: 16945107
Additional info: Recognizes SPG20. Species sequence homology: human.

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