Home  >  Products  >  Spectrin, beta1 (Spectrin beta 1, Beta I Spectrin, Beta Spectrin, HSpTB1, Spectrin beta Chain Erythrocyte, Spectrin beta Erythrocytic (Includes Spherocytosis Clinical Type I), SPTB, SPTB1)
Spectrin, beta1 (Spectrin beta 1, Beta I Spectrin, Beta Spectrin, HSpTB1, Spectrin beta Chain Erythrocyte, Spectrin beta Erythrocytic (Includes Spherocytosis Clinical Type I), SPTB, SPTB1)

Spectrin, beta1 (Spectrin beta 1, Beta I Spectrin, Beta Spectrin, HSpTB1, Spectrin beta Chain Erythrocyte, Spectrin beta Erythrocytic (Includes Spherocytosis Clinical Type I), SPTB, SPTB1)

Cat no: S5380-12A

Supplier: United States Biological
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Spectrin (Sp), the most abundant of the erythrocyte membrane skeleton proteins, helps these cells maintain their characteristic biconcave shape while remaining flexible and elastic. Erythrocyte Sp is a heterodimer composed of a 280kD alpha subunit and a 246kD beta subunit which associate in a side-to-side, antiparallel configuration to form a 100 nm rod-like structure. Sp in other tissues may be composed of distinct but homologous alpha and beta subunits, sometimes referred to as fodrin. A newly introduced nomenclature designates the Sp subunits of the erythrocyte as alpha-1 and beta-1, and the fodrin subunits as alpha-2 and beta-2. Alternatively spliced forms of each are designated as epsilon-1, epsilon-2, etc. (e.g. beta-1 epsilon-1). Applications: Suitable for use in Immunofluorescence and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: S5380-12A
Reactivities: Human, Mouse, Rat
Hosts: Mouse
Applications: Immunofluorescence, Western Blot
Size: 100ul
Form: Supplied as a liquid in PBS, pH 7.2, 0.05% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Ascites
References: This product has been used in:Porter GA et al. Two populations of beta-spectrin in rat skeletal muscle. Cell Motil Cytoskeleton 37:7-19 (1997). Dmytrenko GM et al. Dystrophin in a membrane skeletal network: localization and comparison to other proteins. J Neurosci 13:547-58 (1993). Winkelmann JC & Forget BG Erythroid and nonerythroid spectrins. Blood 81:3173-85 (1993).
Additional info: Detects spectrin from erythrocytes, brain and muscle cells. This antibody has been shown to specifically detect the two known alternatively spliced forms of spectrin, beta-1 epsilon-1, present in erythrocytes, and beta-1 epsilon-2, present in nerve and striated muscle cells. It does not crossreact with alpha-2 spectrin or either of the fodrin subunits. Species Crossreactivity: Crossreacts with Human, Rat and Mouse. Not yet tested in other species.

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