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SOX9 (Transcription Factor SOX-9)

Cat no: S5364-26A

Supplier: United States Biological
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SOX9 has a role in sex determination and differentiation of Sertoli cells. It is involved in chondrogenesis and regulates the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. Translocation of this gene can cause campomelic dysplasia. SOX9 is involved in the formation of testes from the indifferent fetal gonads. It is a major molecular component of the neuron-glia switch in developing spinal cord. During normal development, SOX9 allows the prostate epithelium to outgrow into the mesenchyme and then provides basal cell support for development and maintenance of the luminal epithelium. These functions of SOX9 are subverted in prostate cancer to support tumor growth and invasion. SOX9 may direct the formation of neural crest precursors and the development of a range of neural crest derivative. It has a transcriptional regulation in melanin production in cells. Northern blot analysis shows its expression on adult testis, adult heart, and fetal brain. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 2-5ug/ml Immunohistochemistry (formalin fixed paraffin embedded): 5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S5364-26A
Reactivities: Human, Mouse, Rat, Canine, Feline, Goat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein A affinity chromatography.
References: 1. Morais da Silva, S. et al. Nature Genet. 14: 62-68 (1996). 2. Kanai, Y. et al. Hum. Molec. Genet. 8: 691-696 (1999). 3. Stolt, C. et al. Genes Dev. 17: 1677-1689 (2003). 4. Taylor, K.M. et al. Dev. Cell 9: 593-603 (2005). 5. Passeron, T. et al. Proc. Nat. Acad. Sci. 104: 13984-13989 (2007).
Additional info: Recognizes human SOX9. Species Crossreactivity: feline, chimpanzee, canine, goat, mouse, rat. Species sequence homology: chimpanzee.

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