SorCS2 is a family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. It is noted that all mammalian VPS10 domains carry an N-terminal signal peptide for translocation into the endoplasmic reticulum. The greatest similarity between the receptors is found in the C-terminal parts of the VPS10 domains, which harbor 12 cysteine residues with a characteristic spacing conserved in all VPS10 proteins from yeast to man. SorCS2 is a single-pass type I membrane protein that is highly expressed in brain and kidney. It is also detected at low levels in heart, liver, small intestine, skeletal muscle and thymus.
Applications:
Suitable for use in Western Blot and ELISA. Other applications have not been tested.
Recommended Dilutions:
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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