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Sorcin (SCN, SRI, 22kD Protein, CP22, CP-22, FLJ26259, V19)

Sorcin (SCN, SRI, 22kD Protein, CP22, CP-22, FLJ26259, V19)

Cat no: S5363-01A

Supplier: United States Biological
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Sorcin is a 198aa, soluble, resistance-related, calcium-binding cytosolic protein belonging to the penta-EF hand (PEF) family of calcium binding proteins and contains 4 EF-hand calcium-binding motifs. Human Sorcin is known to share 95% sequence identity with hamster Sorcin. It is known to associate with the sarcolemmal proteins Annexin VII, cardiac ryanodine receptors and L-type Ca2+ channels and thus influence the intracellular Ca (2+)-homeostasis. It is also important in the regulation of intracellular Ca2+ cycling and Ca2+ influx pathways in the heart and skeletal muscle during excitation-contraction. It is overproduced in many multi-drug resistance (MDR) cells and regulates cell apoptosis pathways, thus acting as a new MDR marker for prognosis of acute myeloid leukemia (AML) and a good target for anti-MDR drug development. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Immunohistochemistry (paraffin): 10ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human, mouse and rat brain lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S5363-01A
Reactivities: Human, Mouse, Bovine, Canine, Non-Human Primate
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: 22kD Protein
References: 1. Qi, J. et al. Biochem. Biophys. Res.Commun. 349:303-309 (2006). 2. Meyers, MB. et al. J. Biol. Chem. 278:28865-28871 (2003)
Additional info: Recognizes human Sorcin. Species Crossreactivity: chimpanzee, bovine, canine, equine, monkey, mouse. Species sequence homology: chicken, rat, xenopus, opossum.

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