Somatostatin Receptor Type 5 (Somatostatin Receptor 5, Somatostatin Receptor Subtype 5, SS5R, SSTr5)

Principal Names: Somatostatin receptor 5 (SSTR5); SS5R; Official Gene Symbol: SSTR5 Gen Bank Accession Number: NP_001044 Gene ID: 6755 (human) Gene Map Locus: 16p13.3 (human) Somatostatin is a multifunctional protein affecting exocrine and endocrine protein secretion, neurotransmission, and neuronal modulation and regulating cell proliferation. All these functions of Somatostatin are executed through a class of GPCR protein family members called somatostatin receptor. To date, 6 classes of somatostatin receptors have been discovered out of which SSTR5, 364A.A protein, is a receptor subtype expressed predominantly in the pituitary and hypothalamus region of brain. Studies revealed that SSTR5 contains seven transmembrane regions and undergoes homodimerization and also heterodimerizes with SSTR1. Although the specific functions of SSTR5 are still elusive, the studies indicate that it complements SSTR2 regulation of ACTH secretion. Polymorphisms in SSTR5 gene have been observed in patients with acromegaly. SSTR5 and dopamine type 2 receptors interact physically through heterooligomerization to create a novel receptor with enhanced functional activity (Rocheville et al., 2000). SSTR5 has been reported to be expressed in adrenal, aorta, brain, breast, eye, heart, pancreas, prostate, skeletal muscle, small intestine, and thyroid. ESTs have been isolated from cartilage libraries. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: Paraffin Optimal dilutions to be determined by the researcher. Localization: Plasma membrane Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.