Home  >  Products  >  Solute carrier family 26, member 5 (SLC26A5, Prestin DFNB61, MGC118886, MGC118887, MGC118888, MGC118889, PRES)
Solute carrier family 26, member 5 (SLC26A5, Prestin DFNB61, MGC118886, MGC118887, MGC118888, MGC118889, PRES)

Solute carrier family 26, member 5 (SLC26A5, Prestin DFNB61, MGC118886, MGC118887, MGC118888, MGC118889, PRES)

Cat no: S5330-26A

Supplier: United States Biological
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This gene is a member of the SLC26A/SulP transporter family. It encodes a protein that is specifically expressed in outer hair cells (OHCs) of the cochlea and is essential in auditory processing. Intracellular anions are thought to act as extrinsic voltage sensors, which bind to this protein and trigger the conformational changes required for rapid length changes in OHCs. Mutations in this gene have been associated with non-syndromic hearing loss. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 monthsat -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Peptide Blocking: Corresponding peptide is available for Peptide Blocking studies. See S5330-26A-P. Antibody
Catalogue number: S5330-26A
Reactivities: Human
Hosts: Goat
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in Tris, pH 7.3, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
References: Dallos P, Wu X, Cheatham MA, Gao J, Zheng J, Anderson CT, Jia S, Wang X, Cheng WH, Sengupta S, He DZ, Zuo J. Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification. Neuron 2008 May 58 (3): 333-9
Additional info: Recognizes human SLC26A5.

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