Home  >  Products  >  Solute Carrier Family 10 (SLC10A2, sodium/bile acid cotransporter family), member 2; ASBT; ISBT; ileal apical sodium-dependent bile acid transporter; ileal sodium-dependent bile acid transporter; solute carrier family 10, member 2)
Solute Carrier Family 10 (SLC10A2, sodium/bile acid cotransporter family), member 2; ASBT; ISBT; ileal apical sodium-dependent bile acid transporter; ileal sodium-dependent bile acid transporter; solute carrier family 10, member 2)

Solute Carrier Family 10 (SLC10A2, sodium/bile acid cotransporter family), member 2; ASBT; ISBT; ileal apical sodium-dependent bile acid transporter; ileal sodium-dependent bile acid transporter; solute carrier family 10, member 2)

Cat no: S5329-11

Supplier: United States Biological
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SLC10A2 plays a critical role in reabsorption of bile acids from the the small intestine lumen. Passive flow of sodium ions down their concentration gradient is coupled to bile acid movement, resulting in an increase in the concentration of bile acids in the interior of the cell. This action conserves the body's pool of re-circulating bile acid. SLC10A2 also plays a key role in cholesterol metabolism as cholesterol is the precursor molecule in bile acid synthesis mediated by CYP7A and FXR. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S5329-11
Reactivities: Mouse
Hosts: Goat
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
References: 1. Annaba F, Sarwar Z, Kumar P, Saksena S, Turner JR, Dudeja PK, Gill RK, Alrefai WA. Modulation of ileal bile acid transporter (ASBT) activity by depletion of plasma membrane cholesterol: association with lipid rafts. Am J Physiol Gastrointest Liver Physiol. 2008 Feb;294(2):G489-97. Epub 2007 Dec 6. PMID: 18063707
Additional info: Recognizes mouse SLC10A2. Sequence homology: rat.

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