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SODD (Silencer of Death Domains, BAG Family Molecular Chaperone Regulator 4, BCL2-associated Athanogene 4, BAG4, BAG-4, DKFZp586O2022)

SODD (Silencer of Death Domains, BAG Family Molecular Chaperone Regulator 4, BCL2-associated Athanogene 4, BAG4, BAG-4, DKFZp586O2022)

Cat no: S2000-03

Supplier: United States Biological
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Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, DR5, and DR6 were recently identified. Cell death signal is transduced by death domain containing adapter molecules through the interaction with death domain of these death receptors. A novel TNF-R1 interacting protein was recently identified and designated SODD for silencer of death domains. SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD recruiting to the active TNF-R1 complex, which activates TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines. Applications: Suitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-1:2000 Immunohistochemistry (formalin fixed paraffin embedded): 1:1000-1:5000 Immunoprecipitation: 1:50-1:200 Immunohistochemistry: Frozen Optimal dilutions to be determined by the researcher. Positive Control: Spleen, lymphoid, many cancer cell lines Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S2000-03
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 50ul
Form: Supplied as a liquid, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Takayama S and JC Reed. 2001. Molecular chaperone targeting and regulation by BAG family proteins. Nature Cell Biology. 3:E237-241. 2. Doukhanina EV, S Chen, E van der Zalm, A Godzik, J Reed, and MB Dickman. 2006. Identification and functional characterization of the BAG protein family in Arabidopsis thaliana. JBC 281:18793-18801. 3. H Doong, A Vrailas, EC Kohn. 2002. What's in the BAG?- a functional domain analysis of the BAG-family proteins. Cancer Letters. 188:25-32.
Additional info: Recognizes human BAG-4. Species sequence homology: mouse and rat.

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