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SOCS3, Induced (Suppressor of Cytokine Signaling 3, SOCS-3, Cytokine-inducible SH2 Protein 3, CIS-3, SSI-3, CIS3, SSI3, STAT-induced STAT Inhibitor 3)

Cat no: S1040-03T

Supplier: United States Biological
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Suppressors of cytokine signaling (SOCS) protein family include eight members in humans: SOCS-1 through SOCS-7 and cytokine-inducible Src-homology 2 (SH2) containing protein (CIS). All members of the family have similar structure: variable length (50-380aa) and aa sequence N-terminal region, SH2 domain in the center, and homologous C-terminal 40aa long sequence that was named SOCS box. Studies have demonstrated that animals lacking normal SOCS function exhibit high cytokine activity that leads to a variety of inflammatory and autoimmune diseases and even cancer. SOCS-3 is 225aa long and shares sequence similarity with SOCS- 1. Its expression in many tissues is induced by elevated levels of IL-1, IL-4, IL-6, LIF, GM-CSF, IFNg, GH, EPO, leptin, prolactin, and other cytokines. However, SOCS-3 is found mostly in lungs, spleen, and fat. SOCS-3 targets Janus activated kinases similar to SOCS-1, but with lower affinity and does not block their activity. In addition, SOCS-3 binds phosphorylated tyrosine (Y) residues of various receptors: Y759 of gp130, Y333/338 of GHR, and Y985,1077 of leptin receptor. Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:200-1:500 Immunohistochemistry: 1:100-1:200 Immunoprecipitation: 1:50-1:200 extract from 10e7 cells Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1040-03T
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. HiltonD.J.etal.(1998)Biochemistry 195:114-119. 2. Krebs D. et al. (2001) Stem Cells 19: 378-387. 3. Bullock A. N. et al. (2007) Structure 15(11):1493-1504. 4. Cooney R. N. (2002) Shock 17 (2):83-90. 5. Greenhalgh C.J. et al. (2001) J. of Leuk. Biol. 70: 348-356. 6. Auernhammer C. J. et al. (2001) J. Clin. Invest. 108: 1735-174.
Additional info: Recognizes human SOCS-3. Species sequence homology: mouse and rat.

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