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SnoN (Ski-like Protein, Ski-related Oncogene, Ski-related Protein, SKIL, SNO)

SnoN (Ski-like Protein, Ski-related Oncogene, Ski-related Protein, SKIL, SNO)

Cat no: S1014-66P

Supplier: United States Biological
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TGF-b is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Like Ski, SnoN functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells. There are at least four alternately spliced isoforms of SnoN; SnoN antibody will recognize all isoforms (SnoN, SnoN2, SnoI, and SnoA). Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: A431 lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1014-66P
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified
References: 1. Derynck R, et al (2001) Nat. Genet. 29:117-129. 2. Li Y, et al (1986) J. Virol. 57:1065-72. 3. Luo K (2004) Curr. Op. Gen. Dev. 14:65-70. 4. Massague J, et al (2000) EMBO J. 19:1745-54. 5. Krakowski AR, et al (2005) Proc. Natl. Acad. Sci. USA. 102:12437-42.
Additional info: Recognizes human SnoN. Species Crossreactivity: mouse and rat.

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