Home  >  Products  >  SNF1LK2 (SNF1-like kinase 2, DKFZp434K1115, KIAA0781, LOH11CR1I, QIK, Qin-induced kinase, Serine/threonine-protein kinase SNF1-like kinase 2, SIK2)
SNF1LK2 (SNF1-like kinase 2, DKFZp434K1115, KIAA0781, LOH11CR1I, QIK, Qin-induced kinase, Serine/threonine-protein kinase SNF1-like kinase 2, SIK2)

SNF1LK2 (SNF1-like kinase 2, DKFZp434K1115, KIAA0781, LOH11CR1I, QIK, Qin-induced kinase, Serine/threonine-protein kinase SNF1-like kinase 2, SIK2)

Cat no: S1013-72K

Supplier: United States Biological
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SNF1LK2 (Sucrose non-fermenting 1 like kinase 2) also known as SIK2 (Salt-inducible kinase 2) is a cytoplasmic 125kD member of the CAMK Ser/Thr protein kinase family, AMPK subfamily of enzymes.It is expressed in preadipocytes/adipocytes, with levels strongly induced during early differentiation.SNF1LK2 regulates the early phase of insulin signaling by phosphorylating IRS-1 on Ser794.Human SNF1LK2 is 926 amino acids (aa) in length and contains a protein kinase domain (aa 20-271) with an ATP binding site (Lys49) and a catalytic loop (aa 140-149), followed by a phosphorylation activation site at Thr175, a UBA (ubiquitin-associated) domain (aa 295-335) and another PKA-dependent phosphorylation site at Ser587. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute by adding sterile 40-50% glycerol, aliquot and store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: S1013-72K
Reactivities: Human
Hosts: Goat
Applications: Western Blot
Size: 100ug
Form: Supplied as lyophilized from a 0.2um sterile-filtered solution in PBS with 5% trehalose. Reconstitute in PBS containing 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Additional info: Detects endogenous human SNF1LK2 at 125kD using Western blots.

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