Home  >  Products  >  SNAP 25 (Synaptosomal-associated Protein 25, Synaptosomal Associated Protein 25, Synaptosomal-associated 25kD Protein, Synaptosomal-associated Protein 25kDa, SNAP25, SNAP-25, bA416N4.2, dJ1068F16.2, FLJ23079, HGNC:11132, Resistance to Inhibitors of Cholin
SNAP 25 (Synaptosomal-associated Protein 25, Synaptosomal Associated Protein 25, Synaptosomal-associated 25kD Protein, Synaptosomal-associated Protein 25kDa, SNAP25, SNAP-25, bA416N4.2, dJ1068F16.2, FLJ23079, HGNC:11132, Resistance to Inhibitors of Cholin

SNAP 25 (Synaptosomal-associated Protein 25, Synaptosomal Associated Protein 25, Synaptosomal-associated 25kD Protein, Synaptosomal-associated Protein 25kDa, SNAP25, SNAP-25, bA416N4.2, dJ1068F16.2, FLJ23079, HGNC:11132, Resistance to Inhibitors of Cholin

Cat no: S1014-73C

Supplier: United States Biological
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SNAP 25 (synaptosome-associated protein of 25kD) is a SNAP (soluble N-ethylmaleimide-sensitive fusion (NSF) attachment protein) receptor (SNARE-related protein) which is tightly associated with the plasma membrane by means of the palmitoylation of a cluster of cysteine residues with its structure. SNAP 25 is specifically cleaved close to the carboxyl terminal by the botulinum neurotoxins (BoNT) A and E which are known to inhibit neurotransmitter release. Similar inhibitory effects of BoNT/A and E have been recorded for non-neuronal secretory cells, such as adrenal medulla, This leads to the identification of SNAP 25 in SNARE-like complexes precipitated from chromaffin cells. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 1:500-1:5000. Detects a band at ~26-27kD. Immunohistochemistry (Paraffin): 1:2000-1:5000. No pretreatment or antigen retrieval using heat treatment is required. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1014-73C
Reactivities: Human, Rat, Porcine
Hosts: Mouse
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein A affinity chromatography.
References: 1. Honer, W.G., et al., Hippocampal synaptic pathology in patients with temporal lobe epilepsy. Acta Neuropathol (Berl) 87: 202-210 (1994). 2. Honer, W.G., et al., Human synaptic proteins with a heterogeneous distribution in cerebellum and visual cortex. Brain Res. 609: 9-20 (1993). 3. Honer, W.G., et al., Regional synaptic pathology in Alzheimer's disease. Neurobiol. Aging 13: 375-382 (1992). 4. Honer, W.G., et al., Characterization of a synaptic antigen of interest in neuropsychiatric illness. Biol Psychiatry 31: 147-158 (1992).
Additional info: Recognizes human SNAP 25. Species Crossreactivity: rat and porcine.

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