SNAP-25 is a presynaptic plasma membrane protein which is essential for Ca2+-regulated exocytosis of neurotransmitters. SNAP-25 has been shown to bind to and negatively modulate Ca2+ channels, increasing the speed of neurotransmitter release.
SNAP-25 is expressed by neurons and neuroendocrine cells as two predominant isoforms; SNAP-25a and SNAP-25b. SNAP-25a is expressed early in development, whereas SNAP-25b expression is linked to synaptogenesis. AHP1123 is expected to recognize both isoforms.
SNAP-25 may be a possible therapeutic treatment for sufferers of hyperactivity disorders, while SNAP-25 based peptides may be a possible treatment for involuntary muscle spasms.
Suitable for use in ELISA and Western Blot. Other applications not tested.
Western Blot: 0.01-0.03ug/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.