Home  >  Products  >  SNAP 25, CT (SNAP25, Synaptosomal-Associated protein 25, SNAP-25, Synaptosomal-Associated 25kD Protein, SUP, Super Protein, SNAP, Synaptosomal-Associated Protein, 25kDa)

SNAP 25, CT (SNAP25, Synaptosomal-Associated protein 25, SNAP-25, Synaptosomal-Associated 25kD Protein, SUP, Super Protein, SNAP, Synaptosomal-Associated Protein, 25kDa)

Cat no: S1014-70A


Supplier: United States Biological
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SNAP-25 is a presynaptic plasma membrane protein which is essential for Ca2+-regulated exocytosis of neurotransmitters. SNAP-25 has been shown to bind to and negatively modulate Ca2+ channels, increasing the speed of neurotransmitter release. SNAP-25 is expressed by neurons and neuroendocrine cells as two predominant isoforms; SNAP-25a and SNAP-25b. SNAP-25a is expressed early in development, whereas SNAP-25b expression is linked to synaptogenesis. AHP1123 is expected to recognize both isoforms. SNAP-25 may be a possible therapeutic treatment for sufferers of hyperactivity disorders, while SNAP-25 based peptides may be a possible treatment for involuntary muscle spasms. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Western Blot: 0.01-0.03ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1014-70A
Reactivities: Human, Mouse
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in tris-saline, pH 7.3, 0.02% sodium azide, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Hodel, A. (1998) SNAP-25. Int. J. Biochem. Cell Biol. 30:1069-1073.
Additional info: Recognizes an epitope within the C-terminal region of human SNAP-25. Species Crossreactivity: mouse. Species sequence homology: rat, dog.

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