Smad3 is a 50kD transcriptional modulator activated by TGF-beta and activin type 1 receptor kinase, functioning in cell proliferation, differentiation and development. Upon stimulation, Smad3 oligomerizes with Smad4 and translocates into the nucleus and binds to DNA and transcription factors.
Smad3 activity induces differentiation of selected neuronal subtypes at the expense of other subtypes.
Suitable for use in Immunohistochemistry. Other applications not tested.
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.