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Smac (Diablo Homolog, Mitochondrial, Direct IAP-binding Protein with Low Pi, Second Mitochondria-derived Activator of Caspase, Diablo)

Smac (Diablo Homolog, Mitochondrial, Direct IAP-binding Protein with Low Pi, Second Mitochondria-derived Activator of Caspase, Diablo)

Cat no: S1014-49M

Supplier: United States Biological
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Smac/DIABLO is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates cytochrome c/Apaf-1/caspase-9 pathway. Smac/DIABLO binds to IAPs (Inhibitor of Apoptosis Proteins) and neutralizes the inhibitory effect of IAPs. Analysis of the structural basis of Smac/DIABLO has revealed that the N-terminal aa are required for Smac/DIABLO to bind to IAPs and activation of caspases. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-4ug/ml Immunohistochemistry: 5-20ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1014-49M
Reactivities: Human, Mouse, Rat, Drosophila/Arthropod
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.5% BSA, 5mM EDTA, 0.01% thimerosal, 30% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
Additional info: Recognizes mouse Smac at ~25kD. Species Crossreactivity: human, rat and Drosophila.

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