Home  >  Products  >  SM22 alpha (Smooth Muscle Protein 22-alpha, SM22-alpha, 22kD Actin-binding Protein, Human 22kD Smooth Muscle Protein, SM22, SMCC, Transgelin, TAGLN, TAGLN1, WS3-10)
SM22 alpha (Smooth Muscle Protein 22-alpha, SM22-alpha, 22kD Actin-binding Protein, Human 22kD Smooth Muscle Protein, SM22, SMCC, Transgelin, TAGLN, TAGLN1, WS3-10)

SM22 alpha (Smooth Muscle Protein 22-alpha, SM22-alpha, 22kD Actin-binding Protein, Human 22kD Smooth Muscle Protein, SM22, SMCC, Transgelin, TAGLN, TAGLN1, WS3-10)

Cat no: S1014-32H

Supplier: United States Biological
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TAGLN (Transgelin), otherwise known as SM22-alpha, a shape change sensitive, actin cross-linking/gelling protein, and member of the calponin family, which plays a role in calcium interactions and contractile properties of the cell. TAGLN is ubiquitously expressed by vascular and visceral smooth muscle, and an early marker of smooth muscle differentiation, and also overexpressed by senescent human fibroblasts. Studies have identified TAGLN as a novel tumor suppressor protein, which has a markedly reduced expression in colorectal cancer samples, and may serve as an important biomarker of malignancy. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.01-0.03ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human heart lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1014-32H
Reactivities: Human
Hosts: Goat
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: DKFZp686B01212, DKFZp686P11128, Protein WS3-10
References: 1. Nishida W, Kitami Y, Abe M, Hiwada K. Gene cloning and nucleotide sequence of SM22 alpha from the chicken gizzard smooth muscle. Biochem Int. 1991 Mar;23(4):663-8. 2. Donoghue P. et al.: Proteomic profiling of chronic low-frequency stimulated fast muscle. Proteomics. 2007 Sep;7(18):3417-30. PMID: 17708595.
Additional info: Recognizes human SM22-alpha/Transgelin. Species sequence homology: mouse, rat, canine, bovine.

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