Home  >  Products  >  SLIT2 (Slit Homolog 2 (Drosophila), Slit Homolog 2, Slit Homolog 2 Protein, Slit-2, Drad-1, E030015M03Rik, E130320P19Rik, FLJ14420, HGNC:11086, Slil3)
SLIT2 (Slit Homolog 2 (Drosophila), Slit Homolog 2, Slit Homolog 2 Protein, Slit-2, Drad-1, E030015M03Rik, E130320P19Rik, FLJ14420, HGNC:11086, Slil3)

SLIT2 (Slit Homolog 2 (Drosophila), Slit Homolog 2, Slit Homolog 2 Protein, Slit-2, Drad-1, E030015M03Rik, E130320P19Rik, FLJ14420, HGNC:11086, Slil3)

Cat no: S1014-19K

Supplier: United States Biological
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Slit proteins are ligands at the Roundabout (Robo) receptors and act as guidance cues in axonal migration/navigation during neural development, at the ventral midline of the neural tube. Slit1 and Slit2 are essential for midline guidance in the forebrain by acting as repulsive signals preventing inappropriate midline crossing by axons projecting from the olfactory bulb. A number of cleavage products are reported in the literature for Slit2 proteins (following alternate splicing). The C-terminal cleavage proteins are more diffusible than the larger N-terminal protein that is more tightly cell associated. Slit2 protein is expressed in fetal lung and kidney, and adult spinal cord. Weak expression in adult adrenal gland, thyroid, trachea. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:1500-1:6000 Western Blot: 1:500-1:2000 detects a band at 165kD. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1014-19K
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Little M et al. Conserved modularity potential for alternate splicing in mouse human Slit genes. Int J Dev Biol 46:385-91 (2002). PUBMED:12141424Nguyen-Ba-Charvet KT Ch
Additional info: Recognizes human SLIT2. Species sequence homology: mouse, rat and xenopus.

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