Home  >  Products  >  SLIT1 (Slit Homolog 1, Slit Homolog 1 Protein, Slit-1, KIAA0813, Multiple Epidermal Growth Factor-like Domains 4, MEGF4, OTTHUMP00000059392, SLIL1, SLIT3, SLIT-3)
SLIT1 (Slit Homolog 1, Slit Homolog 1 Protein, Slit-1, KIAA0813, Multiple Epidermal Growth Factor-like Domains 4, MEGF4, OTTHUMP00000059392, SLIL1, SLIT3, SLIT-3)

SLIT1 (Slit Homolog 1, Slit Homolog 1 Protein, Slit-1, KIAA0813, Multiple Epidermal Growth Factor-like Domains 4, MEGF4, OTTHUMP00000059392, SLIL1, SLIT3, SLIT-3)

Cat no: S1014-19G

Supplier: United States Biological
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Slit proteins are ligands at the Roundabout (Robo) receptors and act as guidance cues in axonal migration/navigation during neural development, at the ventral midline of the neural tube. Slit1 and Slit2 are essential for midline guidance in the forebrain by acting as repulsive signals preventing inappropriate midline crossing by axons projecting from the olfactory bulb. Alternative splicing isoforms have been identified for Slit1 protein. Slit1 is predominantly expressed in adult forebrain, though also expressed in fetal brain, lung and kidney. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: S1014-19G
Reactivities: Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: As reported
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: Tanno T et al. Expression and Function of Slit1{alpha}, a Novel Alternative Splicing Product for Slit1. J Biochem (Tokyo) 136:575-581 (2004). PubMed: 15632296 Little M et al. Conserved modularity and potential for alternate splicing in mouse and human Slit genes. Int J Dev Biol 46:385-91 (2002). PubMed: 12141424Little M et al. Conserved modularity and potential for alternate splicing in mouse and human Slit genes. Int J Dev Biol 46:385-91 (2002). PubMed: 12141424. Search PubMed (MEDLINE) for references to Slit1
Additional info: Species Crossreactivity: Reacts with Mouse and Rat.

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