Home  >  Products  >  SLC5A3, CT (Solute Carrier Family 5 Member 3, Na(+)/myo-inositol Cotransporter, Sodium/myo-inositol Cotransporter, SMIT, Sodium/myo-inositol Cotransporter 1)

SLC5A3, CT (Solute Carrier Family 5 Member 3, Na(+)/myo-inositol Cotransporter, Sodium/myo-inositol Cotransporter, SMIT, Sodium/myo-inositol Cotransporter 1)

Cat no: S5328-94D


Supplier: United States Biological
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SLC5A3, also known as SMIT-1, is a membrane associated transporter which is expressed in many human tissues including the brain, kidney and placenta. It is up-regulated in hypertonic conditions and functions in cellular osmoregulation by regulating myo-inositol (MI) uptake. MI is the precursor for phosphatidylinositol and its derivatives, all of which have functions in signal transduction. It is approximately 80kD in size. Up-regulation of SLC5A3 may be associated with an increased risk for bipolar I disorder, and is also thought to be a factor in the pathophysiology of Down syndrome. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 10-30ug/ml Requires antigen retrieval using heat treatment prior to staining of paraffin sections. Optimal dilutions to be determined by the researcher. Positive Control: Spinal cord Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S5328-94D
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.7, 0.09% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Mallee, J.J. et al. (1997) The structural organization of the human Na+/myo-inositol cotransporter (SLC5A3) gene and characterization of the promoter. Genomics. 46: 459-465. 2. Chau, J.F. et al. (2005) Sodium/myo-inositol cotransporter-1 is essential for the development and function of the peripheral nerves. FASEB J. 19: 1887-1889. 3. Willmroth, F. et al. (2007) Sodium-myo-inositol co-transporter (SMIT-1) mRNA is increased in neutrophils of patients with bipolar 1 disorder and down-regulated under treatment with mood stabilizers. Int. J. Neuropsychopharmacol. 10: 63-71.
Additional info: Recognizes an epitope within the C-terminal region of human SLC5A3.

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