SLC5A3, also known as SMIT-1, is a membrane associated transporter which is expressed in many human tissues including the brain, kidney and placenta. It is up-regulated in hypertonic conditions and functions in cellular osmoregulation by regulating myo-inositol (MI) uptake. MI is the precursor for phosphatidylinositol and its derivatives, all of which have functions in signal transduction. It is approximately 80kD in size.
Up-regulation of SLC5A3 may be associated with an increased risk for bipolar I disorder, and is also thought to be a factor in the pathophysiology of Down syndrome.
Suitable for use in Immunohistochemistry. Other applications not tested.
Immunohistochemistry (paraffin): 10-30ug/ml
Requires antigen retrieval using heat treatment prior to staining of paraffin sections. Optimal dilutions to be determined by the researcher.
Positive Control: Spinal cord
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.