Home  >  Products  >  SLC10A1 (Sodium/Bile Acid Cotransporter, Cell Growth-inhibiting Gene 29 Protein, Na(+)/bile Acid Cotransporter, Na(+)/taurocholate Transport Protein, Sodium/Taurocholate Cotransporting Polypeptide, Solute Carrier Family 10 Member 1, NTCP, GIG29)
SLC10A1 (Sodium/Bile Acid Cotransporter, Cell Growth-inhibiting Gene 29 Protein, Na(+)/bile Acid Cotransporter, Na(+)/taurocholate Transport Protein, Sodium/Taurocholate Cotransporting Polypeptide, Solute Carrier Family 10 Member 1, NTCP, GIG29)

SLC10A1 (Sodium/Bile Acid Cotransporter, Cell Growth-inhibiting Gene 29 Protein, Na(+)/bile Acid Cotransporter, Na(+)/taurocholate Transport Protein, Sodium/Taurocholate Cotransporting Polypeptide, Solute Carrier Family 10 Member 1, NTCP, GIG29)

Cat no: S5329-10W

Supplier: United States Biological
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Na+-taurocholate cotransporting polypeptide (NTCP), also known as SLC10A1 (Solute carrier family 10,member 1) is the major bile acid uptake system in human hepatocytes. NTCP and the ileal transporter ASBT (apical sodium-dependent bile acid transporter) are two sodium-dependent transporters critical for the enterohepatic circulation of bile acids. The hASBT gene is known to be activated by the glucocorticoid receptor (GR). Ho RH et al. indicates functionally important polymorphisms in NTCP exist and that the likelihood of being carriers of such polymorphisms is dependent on ethnicity. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: S5329-10W
Reactivities: Human, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a lyophilized powder from PBS, pH 7.4, 5% BSA, 0.05% thimerosal, 0.05% sodium azide. Reconstitute with 200ul sterile ddH2O.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Eloranta JJ et al., Mol Endocrinol 20(1):65-79 (2006) 2. Ho R.H. et al., J Biol. Che 279(8): 7213-22 (2004).
Additional info: Recognizes human NTCP. Species Crossreactivity: rat

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