Home  >  Products  >  SIK2 (Serine/Threonine-protein Kinase SIK2, Qin-induced Kinase, Salt-inducible Protein Kinase 2, SIK-2, Serine/Threonine-protein Kinase SNF1-like Kinase 2, KIAA0781, QIK, SNF1LK2)
SIK2 (Serine/Threonine-protein Kinase SIK2, Qin-induced Kinase, Salt-inducible Protein Kinase 2, SIK-2, Serine/Threonine-protein Kinase SNF1-like Kinase 2, KIAA0781, QIK, SNF1LK2)

SIK2 (Serine/Threonine-protein Kinase SIK2, Qin-induced Kinase, Salt-inducible Protein Kinase 2, SIK-2, Serine/Threonine-protein Kinase SNF1-like Kinase 2, KIAA0781, QIK, SNF1LK2)

Cat no: S1013-72M

Supplier: United States Biological
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SIK2 is a cytoplasmic 125kD member of the CAMK Ser/Thr protein kinase family, AMPK subfamily of enzymes.It is expressed in preadipocytes/adipocytes, with levels strongly induced during early differentiation. SNF1LK2 regulates the early phase of insulin signaling by phosphorylating IRS-1 on Ser794.Human SNF1LK2 is 926aa in length and contains a protein kinase domain (aa20-271) with an ATP binding site (Lys49) and a catalytic loop (aa140-149), followed by a phosphorylation activation site at Thr175, a UBA (ubiquitin-associated) domain (aa295-335) and another PKA-dependent phosphorylation site at Ser587. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-3ug/ml Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml IOptimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1013-72M
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Purity: Purified by Protein G affinity chromatography.
Additional info: Recognizes human SIK2. Species sequence homology: Bovine, chimpanzee, canine, mouse and rat.

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