Home  >  Products  >  SIGIRR (Single Ig IL-1-Related Receptor, Single Ig IL-1R-Related Molecule, Single Immunoglobulin Domain-Containing IL1R-Related Protein, Toll/Interleukin-1 Receptor 8, TIR8, UNQ301/PRO342)
SIGIRR (Single Ig IL-1-Related Receptor, Single Ig IL-1R-Related Molecule, Single Immunoglobulin Domain-Containing IL1R-Related Protein, Toll/Interleukin-1 Receptor 8, TIR8, UNQ301/PRO342)

SIGIRR (Single Ig IL-1-Related Receptor, Single Ig IL-1R-Related Molecule, Single Immunoglobulin Domain-Containing IL1R-Related Protein, Toll/Interleukin-1 Receptor 8, TIR8, UNQ301/PRO342)

Cat no: S1013-68H

Supplier: United States Biological
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The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). TIR8, also know as single Ig IL-1 receptor, is a member of the IL-1:TLR superfamily (2). TIR8 acts as intracellular decoy to inhibit NF-kappaB activation by members of the IL-1:TLR family (3, 4). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human or mouse kidney Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1013-68H
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity Chromatography.
Alternative names: Single Immunoglobulin and Toll-interleukin 1 Receptor (TIR) Domain, HGNC:30575, MGC110992
References: 1. Muzio M, Natoli G, Saccani S, Levrero M, and Mantovani A. J. Exp. Med. 187:2097-2101 (1998). 2. Thomassen E, Renshaw BR, and Sims JE. Cytokine 11: 389-399 (1999). 3. Polentarutti N, Penton R, Muzio G, et al. Eur Cytokine Network 14: 1-8 (2003). 4. Wald D, Qin J, Zhao Z, et al. Nat. Immunol. 4: 920-927 (2003).
Additional info: Recognizes human TIR8. Species Crossreactivity: mouse.

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