Home  >  Products  >  Sialoprotein, Bone (BSP, Bone Sialoprotein 2, BSP2, Cell-binding Sialoprotein, Integrin-binding Sialoprotein)

Sialoprotein, Bone (BSP, Bone Sialoprotein 2, BSP2, Cell-binding Sialoprotein, Integrin-binding Sialoprotein)

Cat no: S1013-36A

Supplier: United States Biological
0 reviews | Write a Review Pencil
Bone sialoprotein (BSP) is one of the major noncollagenous proteins in the extracellular matrix of bone. It is a phosphorylated glycoprotein with an approximate molecular weight of 70-80kD. The protein has been found in osteoblasts and osteocytes. BSP is synthesized and secreted by bone-, dentin- and cementum-forming cells. Diseases concerning the bone turnover, pathological bone alterations as well as the rapid increase of osteoporosis make it necessary to establish new markers. Bone sialoprotein is discussed as a potential serum marker for monitoring bone remodelling. Applications: Suitable for use in ELISA, Western Blot, Immunohistochemistry, RIA, Immunocytochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin and frozen): 1:100 Immunocytochemistry: 1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: S1013-36A
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Immunocytochemistry, Immunohistochemistry, Western Blot
Size: 10ug
Form: Supplied as a lyophilized powder in 50mM Tris, pH 7.2. Reconstitute with 10ul sterile ddH2O.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
References: 1. Wuttke M, Muller S, Nitsche P, Paulsson M, Hanisch FG, Maurer P. Structural characterization of human recombinant and bone-derived bone sialoprotein (BSP) Functional implications for cell attachment and hydroxyapatite binding. J Biol Chem 2001. 2. Ibrahim T, Leong I, Sanchez-Sweatman O, Khokha R, Sodek J, Tenenbaum HC et al. Expression of bone sialoprotein and osteopontin in breast cancer bone metastases. Clin Exp Metastasis 2000;18:253-60.
Additional info: Recognizes human Bone Sialoprotein and recombinant human BSP. There were no cross reactivities obtained with bovine BSP, porcine BSOP, rat BSP, human Osteonectin and human Osteopontin.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*

Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave