Home  >  Products  >  SHPRH (SNF2 Histone-linker PHD RING-finger Helicase, 2610103K11RIK, bA545I5.2, FLJ27258, FLJ37625, FLJ45012, FLJ90837, KIAA2023, MGC134886)
SHPRH (SNF2 Histone-linker PHD RING-finger Helicase, 2610103K11RIK, bA545I5.2, FLJ27258, FLJ37625, FLJ45012, FLJ90837, KIAA2023, MGC134886)

SHPRH (SNF2 Histone-linker PHD RING-finger Helicase, 2610103K11RIK, bA545I5.2, FLJ27258, FLJ37625, FLJ45012, FLJ90837, KIAA2023, MGC134886)

Cat no: S1013-30W3

Supplier: United States Biological
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SHPRH is a member of the SWI/SNF family of ATPaes/helicases, it posesses a C3HC4 RING motif characteristic of ubiquitin ligase protein and it has a fundamental role in DNA repair mechanism. Upon genotoxic stress, SHPRH associates with PCNA, RAD18, and the ubiquitin-conjugating enzyme UBC(E2) and promotes methyl methanesulfonate (MMS)-induced PCNA polyubiquitation suppressing genomic instability. SHPRH gene is mutated in a number of cancer cell lines, including those from melanomas and ovarian cancer. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:500 Western Blot: 1:500 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: S1013-30W3
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 1mg
Form: Supplied as a liquid in PBS, pH 7.2.
P type: Pab
Purity: Purified by Protein G affinity chromatography.
References: Sood, R. et al. (2003) Genomics 82,153-161. Unk, I. et al. (2006) Proc. Natl. Acad. Sci 103, 18107-18112. Motegi, A. et al. (2006) J. Cell Biol. 175,703-708.
Additional info: Recognizes human SHPRH

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